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Native Answers Coronavirus Related Basic Science Questions

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Native

ToungeInCheek since 2010
Staff member
10 Year Member
Basically, we are moving into an era of a hot mess of data. Variables on top of variables that will make good data and information hard to find. There will be data to support whatever position you want to further on this latest omicron wave that appears to about to begin.

Each study now not only has regional and age and environmental differences, but we can compare at least 4 different iteration of the virus, on top of many, many variations of vaccination /natural infection statuses. J&J, boosted or not. Pfizer, 1,2, or 3 doses? How long ago did you get vaccinated? Moderna likewise. Natural infection, NI + booster? Again, when did you get those shots etc.

Movement of the virus in a previously infected/vaccinated population? What are vaccination rates, what is prior infection case report.... again, when did it happen..... Like I said, data hot mess.

(But don't worry, there are a couple of dudes over in hot topics who have it all figured out). ;) :Banana: :Banana::Banana:
 

Native

ToungeInCheek since 2010
Staff member
10 Year Member

Here is an early version of an attempt to look at omicron with many of the variables in play that I talked about one post up.

Pre-preprint, but appears to be solid standard techniques used.
 

Native

ToungeInCheek since 2010
Staff member
10 Year Member
For anyone who hates their local quarantine policy….. this is what needs done. A much smarter/refined approach to quarantine policy.


 

Native

ToungeInCheek since 2010
Staff member
10 Year Member
TL : DR

Vaccination protects against Covid-19 hospitalization significantly more than prior infection, according to CDC study



This makes sense because vaccination provides antigen at a consistently high enough level to illicit a solid immune response that is prolonged enough to get T-cell activation. (T-Cells gonna kill virus infected cells, stopping spread of disease.) My guess is that protection is greater in Pfizer/Moderna than J&J.

Prior infection is protective too, but we aren't able to look at a stratified sampling of previous disease. Greater symptoms with full on covid infection likely have the highest level of protection amount the previously infected. More disease burden, more response, thus more downstream protection. Prior infection most at risk would be those who got a low dose infection and had mild/asymptomatic infection, thus a weaker immune response that may have lacked robust antibody development and T-cell response.
 
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