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Native Answers Coronavirus Related Basic Science Questions

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Native

ToungeInCheek since 2010
Staff member
10 Year Member
Great nuanced thread about gain of function research. Also a relatively polite science fight. I’m #teambloom.

 

Native

ToungeInCheek since 2010
Staff member
10 Year Member
My take has been consistently been that masks are an element that have to have a level of risk reduction associated with them. Are they perfect as used by kids, adults, and most people in society. Not at all. But even with their imperfections they are a component is preventing the spread of SARS-CoV-2.

 

Native

ToungeInCheek since 2010
Staff member
10 Year Member
Something I posted in "the cafe". I occasionally get drug over there. This time I blame @KleinTxHusker. Anyway:

I am not typing in to the void!

Technical correction, antibodies are part of the immune system. Will do a very short primer.

Innate Immunity. Things you have that work against any pathogen. Neutrophils, stomach acid, lysozyme in tears, ciliary action in lungs... etc. etc.

Adaptive immunity: The part of the immune system that adapts and responds to pathogens and improves with time.

This can be broken down into cellular immunity and humoral immunity.
Humoral immunity: Antibody production. This is done by B-cells. Given the correct cytokine stimulation you can get memory B-cells or plasma cells. both crank out antibodies, the plasma cells probably giving the highest amount of antibody production. Memory B cells stick around so at a later date you can make antibodies again in the event of another challenge. (they don't get lost to lack of use by a booster) Booster also keeps circulating antibodies high so immune system is ready to go.

Cellular immunity: Here, T-Cells, Natural Killer cells. These cells have been adapted specifically to recognize virus infected cells or bad cells (cancer) in the body. So when you have an infection going on you are able to wipe out the actual infected cell and not let the virus spread.


This is a huge generalization of what is known and incomplete retelling. But when you get an antibody test you are only looking at one aspect of viral resistance, and that is circulating antibody. Testing for the t-cells/NK cells and even the memory B-cells is all significantly more difficult.


Side note: From the get go I have been #TeamModerna due to the fact they had been in the game longer and I know they had to be working on things to optimize the cellular immunity portion of the response. I say this, as a lot of their goal was/is a cancer vaccine, which is infinitely more difficult and really needs to involve the cellular immunity component of the host response.
 

Native

ToungeInCheek since 2010
Staff member
10 Year Member
And MORE booster talk. This guy and Crotty from the post above are solid follows on all things covid. I just listened to Crotty give a talk to Infectious disease society....


 
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